Prognosis for Metastatic Breast Cancer — Metastatic is the spreading of cancer cells from the primary tumor to vital organs or distant places on the patient’s body. The process is the result of a series of changes to genetic, epigenetic events and reactions the body against tumor. Metastasis is the central feature on the malignant tumor or that we know with cancer. Metastatic cancer requires an activation of effector genes or gene inaktivation metastasis–suppressor gene metastatic Cascade line is different and more complex than a cascade of tumorigenesis. This concept fits with discovery Kang et al. stating that for certain organ to a metastasis of cancer require specific gene expression of laden who is attached to the primary tumor bad profile. The spread of cells depends on the quantity of the component molecules like adhesion receptors, extracellular, Ligand affinity metrics between membrane receptors and chemoatractan, the enzymes protease, a protein–specific proteins that are bound to a particular cell and molecular skeleton.